LAMICTAL DISPERSIBLE/CHEWABLE TABLETS NAME OF THE MEDICINE: The chemical name for lamotrigine is 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (CAS

NEW ZEALAND DATA SHEET Lamictal Dispersible/Chewable Tablets

Toxic epidermal necrolysis after treatment with lamotrigine (Lamictal®)

Toxic epidermal necrolysis (TEN) is a rare, but very severe cutaneous disorder characterized by necrosis of keratinocytes leading to a loosening of the epidermis’**. As a consequence, lifethreatening dehydration and severe infections may occur. TEN can occur as a result of an adverse reaction to drugs (i.e. Lye11 syndrome) or may be the result of staphylococcal toxins (i.e. staphylococcal scald...

SYNTHESIS OF SELENAZOL0[3,2-b] [ 1,2,4] TRIAZINE AND SELENAZOLO [2,3-C] [I ,2,4] TRIAZINE

6-Methyl- 1,2,4-triazine-3-(2H)-selenone-5(4H)-one(l) reacts in the presence of base with phenacyl bromide to give a mixture of compounds (2) and (3). This mixture is dehydrated in the presence of H,SO, to give 3-phenyl-6 methyl-7H-selenazolo[3,2-b] [I ,2,4] triazin-7-one (6). For careful structure assignment of (6) its regioisomer 3-methyl-6-phenyl-4H-selenazolo [2,3-c] [ 1,2,4] triazin-4-one...

Ring Cleavage of Some Bicylic Compounds Derived from 1,2,4-Triazine

Ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield N-substituted triazines (7) and (8). These confirm the given configuration assigned to the isomeric triazinotriazines. 6-Methyl-2-phenyl-7H-oxazolo [3,2-b][1,2,4]-triazin-7-one (9) underwent ring cleavage on treatment with sodium alkoxide to afford 3-alkoxy-1...

Lyell syndrome and epileptic seizures after confusion between Lamictal and Lamisil.

These two brand names are too similar, while the international non-proprietary names (INNs) are clearly different: lamotrigine (an antiepileptic) and terbinafine (an antifungal drug).